Peptide lip treatments are the latest must-have for hydrating, smoothing, and plumping lips. These high-tech formulas claim to boost collagen production, reduce fine lines, and enhance lip fullness over time. But do they really work?

In a recent Allure article, Dr. Kiran Mian of Hudson Dermatology & Laser Surgery and other board-certified dermatologists shared their insights on how peptide lip treatments work, their benefits, and which products truly deliver results.

Dr. Mian particularly highlighted Biossance Pro-Peptide Lip Perfector, praising its encapsulated hyaluronic acid and peptide complex for providing deep hydration and improving lip texture. She emphasized that consistency is key, as peptides take time to stimulate collagen and improve lip fullness.

What Are Peptide Lip Treatments?

Peptide lip treatments are designed to hydrate, repair, and plump lips by boosting collagen production. Peptides are small amino acid chains that signal the skin to produce more collagen, which helps maintain firmness, elasticity, and hydration.

Key Benefits of Peptide Lip Treatments:

• Hydrates and nourishes lips – Helps repair chapped lips and improve moisture retention.
• Boosts collagen production – Over time, peptides can enhance lip volume and reduce fine lines.
• Softens and smooths texture – Helps lips feel plumper and more youthful.

However, Dr. Mian and other experts caution that results take time. Peptide lip treatments work best when used consistently, and while they won’t replace lip fillers, they can be a great daily lip care solution.

Top Dermatologist-Approved Peptide Lip Treatments

The article rounds up the best peptide lip treatments, each chosen for its hydration, plumping effects, and high-quality ingredients.

1. Best Overall: Iris & Romeo Power Peptide Lip Balm

• Why it stands out: Features bio-mimetic peptides and rosehip oil for deep hydration.
• Best for: Those looking for a tinted, nourishing lip treatment.

2. Best for Fine Lines: Paula’s Choice Pro-Collagen Peptide Gloss Balm

• Why it stands out: Contains three powerful peptides, plus squalane and shea butter for extra hydration.
• Best for: Smoothing fine lines and wrinkles on the lips.

3. Best Budget: The Inkey List Tripeptide Plumping Lip Balm

• Why it stands out: An affordable peptide-packed formula that hydrates and volumizes.
• Best for: Daily lip hydration on a budget.

4. Best for Chapped Lips: Biossance Pro-Peptide Lip Perfector

• Why it stands out: Dr. Kiran Mian’s top pick—it features encapsulated hyaluronic acid and a patented peptide complex for long-lasting hydration.
• Best for: Repairing dry, peeling lips while delivering a soft, plump finish.

Dr. Kiran Mian’s Expert Advice on Peptide Lip Treatments

Dr. Mian explains that peptide lip treatments are most effective when used consistently. Unlike instant-plumping formulas that rely on irritating ingredients like cinnamon or menthol, peptides work by stimulating collagen over time, meaning results become more noticeable after several weeks of use.

She also emphasizes the importance of choosing the right product:

• Look for multi-peptide formulas – A blend of peptides works better than just one.
• Hydration matters – Ingredients like hyaluronic acid, ceramides, and squalane help lock in moisture.
• Be realistic about results – Peptides can improve lip texture and fullness, but they won’t replace fillers or in-office treatments.

For those looking to maintain soft, hydrated, and fuller-looking lips, Dr. Mian recommends incorporating a peptide lip treatment into a daily routine, alongside proper hydration and UV protection to prevent premature aging.